The Importance of Early Recognition of Extrapyramidal Symptoms (EPS) in a Community Mental Health Clinic
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The risk factors of EPS in Chinese patients with schizophrenia and its relationship with psychiatric symptoms and mood symptoms of schizophrenia remain unknown. Compared with the non-EPS group, the EPS group patients are older, and they have a longer duration since first prescribed antipsychotics. The EPS group patients have higher frequency of atypical antipsychotics polytherapy and typical and atypical antipsychotics polytherapy or combined treatments with mood stabilisers.
They often show up a few hours after your first dose but can show up anytime within the first few weeks. Timing may depend on the specific side effect. Delayed symptoms can happen after you’ve been taking the drug for some time. With akathisia, you may feel very restless or tense and have a constant desire to move. In children, this might show up as physical discomfort, agitation, anxiety, or general irritability. You might find that pacing, shaking your legs, rocking on your feet, or rubbing your face helps ease the restlessness. Research suggests risk of akathisia increases with higher doses of medication. Akathisia symptoms have also been associated with a higher risk of another condition called tardive dyskinesia. Anywhere from 5 to 36 percentTrusted Source of people taking antipsychotics may develop akathisia. Some medications, including beta-blockers, may help relieve symptoms. Lowering the dose of antipsychotic medication may also lead to improvement. Dystonic reactions are involuntary muscle contractions. These movements are often repetitive and might include eye spasms or blinking, twisting head, protruding tongue, and extended neck, among others. Movements might be very brief, but they could also affect your posture or stiffen your muscles for a period of time. They most often affect your head and neck, though they can occur in other parts of your body. Dystonia can cause painful muscle stiffness and other discomfort. You can also choke or have trouble breathing if the reaction affects muscles in your throat.
Apart from antipsychotic drugs, dopamine antagonists used as anti-emetics or sedatives (prochlorperazine, metoclopramide), anticonvulsants, antimalarials, stimulants and serotonergic agents have been implicated. Dystonias are encountered with levodopa during the course of treatment of Parkinson’s disease. Toxins (manganese, carbon monoxide, carbon disulfide) have also been implicated.
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