Is Acetylcholine Excitatory or Inhibitory?
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Unlike the other synapses, non-channel synapses comprise of membrane-bound enzymes instead of channel to be the neuroreceptor. When the neurotransmitters bind to the receptor, a series of chemical reaction will be triggered inside the cell. These synapses are usually involved in slow and long-lasting responses. Neuromuscular junctions are the synapses the found between motor neurons and muscle cells connecting the nervous system to muscular system.
The ability of acetylcholine to coordinate the response of neuronal networks in many brain areas makes cholinergic modulation an essential mechanism underlying complex behaviors.Acetylcholine (ACh) is a fast-acting, point-to-point neurotransmitter at the neuromuscular junction and in the autonomic ganglia; however, there are fewer demonstrations of similar actions in the brain (Changeux, 2010). Instead, central cholinergic neurotransmission predominantly changes neuronal excitability, alters presynaptic release of neurotransmitters, and coordinates the firing of groups of neurons (Kawai et al., 2007).
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