What Behaviors Are Associated With Acetylcholine?
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Most subcortical areas are innervated by neurons from the ponto-mesencephalic region.
It was discovered by Henry Hallett Dale in 1914, and its existence was later confirmed by Otto Loewi. Both individuals were awarded the Nobel Prize in Physiology/Medicine in 1936 for their discovery. Within the autonomic system, acetylcholine controls a number of functions by acting on preganglionic neurons in the sympathetic and parasympathetic systems. It is also the neurotransmitter released at all parasympathetic innervated organs, promoting contraction of smooth muscles, dilation of blood vessels, increased body secretions, and a slower heart rate. For example, the brain might send out a signal to move the right arm. The signal is carried by nerve fibers to the neuromuscular junctions. The signal is transmitted across this junction by the acetylcholine neurotransmitter, triggering the desired response in those specific muscles. Acetylcholine also acts at various sites within the central nervous system where it can function as a neurotransmitter and as a neuromodulator. It plays a role in motivation, arousal, attention, learning, and memory, and is also involved in promoting REM sleep.
Acetylcholine may enhance encoding by increasing the strength of afferent input relative to feedback, by contributing to theta rhythm oscillations, by activating intrinsic mechanisms for persistent spiking, and by increasing the modification of synapses. These effects may enhance different types of encoding in different cortical structures. In particular, the effects in entorhinal and perirhinal cortex and hippocampus may be important for encoding of new episodic memories (Gil Z, Conners BW, 1997). Pharmacological studies in human subjects conclusively demonstrate that blockade of muscarinic cholinergic receptors by drugs such as scopolamine impairs the encoding of new memories, but not the retrieval of previously stored memories, and impairs working memory for some stimuli. Conversely, drugs which activate nicotinic receptors enhance the encoding of new information. This article will discuss how the specific cellular effects of acetylcholine within cortical structures could underlie the role of acetylcholine in encoding of new memories.
Acetylcholine normally enhances cortical sensitivity to external stimuli and decreases corticocortical communication, increasing focused attention. However, increases in ACh signaling can lead to symptoms related to anxiety and depression. For example, while stress-induced ACh release can result in adaptive responses to environmental stimuli, chronic elevations in cholinergic signaling may produce maladaptive behaviors.
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