What Is a G-Protein-Linked Receptor?
GPCRs are the largest family of membrane proteins and mediate most cellular responses to hormones and neurotransmitters, as well as being responsible for vision, olfaction and taste. At the most basic level, all GPCRs are characterized by the presence of seven membrane-spanning α-helical segments separated by alternating intracellular and extracellular loop regions. GPCRs in vertebrates are commonly divided into five families on the basis of their sequence and structural similarity.
This brought about the “fight-or-flight” response among other things. Robert Lefkowitz, in the 80’s introduced “the modern study of GPCRs by first cloning and sequencing the genes for the BARs.”
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