How Do the G-Protein-Linked Receptor and an Ion Channel Differ From Each Other?
Binding of a ligand to a receptor changes its shape or activity, allowing it to transmit a signal or directly produce a change inside of the cell.
M). This review will highlight some examples of ion channel receptor interactions and their potential clinical utility for neuroprotection.
Perhaps the most important principle to keep in mind is that the response elicited by a given neurotransmitter is determined by the postsynaptic complement of receptors and their associated channels. Exactly how postsynaptic responses are produced by some especially important examples of neurotransmitter receptors is considered in the following sections.
Hollmann M., Boulter J., Maron C., Beasley L., Sullivan J., Pecht G., et al. (1993). Zinc potentiates agonist-induced currents at certain splice variants of the NMDA receptor. Neuron 10
Jarvis S. E., Magga J. M., Beedle A. M., Braun J. E., Zamponi G. W. (2000). G protein modulation of N-type calcium channels is facilitated by physical interactions between syntaxin 1A and Gbetagamma. J. Biol. Chem. 275
Kalia L. V., Pitcher G. M., Pelkey K. A., Salter M. W. (2006). PSD-95 is a negative regulator of the tyrosine kinase Src in the NMDA receptor complex. EMBO J. 25, 4971–4982